Circadian Rhythms of Granzyme B, Perforin,

Circadian rhythms of granzyme B, perforin, IFN-gamma, and NK cell cytolytic activity in the spleen: effects of chronic ethanol.

Recent studies show that alterations in the body's biological rhythms can lead to serious pathologies, including cancer. Acute and chronic ethanol consumption impairs the immune system by causing specific defects in the cellular components of the innate immune response and by creating increased risk and susceptibility to infections and cancer. NK cells are critical for immune surveillance again...

Circadian Rhythms of Granzyme B, Perforin, IFN- , and NK Cell Cytolytic Activity in the Spleen: Effects of Chronic Ethanol

Interaction of perforin and granzyme B and HTLV-1 viral factors is associated with ATL development

Objective(s): Human T cell leukaemia virus type 1 (HTLV-1) is associated with adult T cell leukaemia (ATL), a malignant lymphoproliferative disease that infects CD4 T cells. It is not clear why the majority of HTLV-1-infected individuals remain asymptomatic carries (ACs) and a minority develop ATL. Cellular immune response has a critical role in ATL and destroys malign...

Biol. Pharm. Bull. 30(4) 621—626 (2007)

logical functions, including metabolism, cell growth, etc. The master pacemaker of circadian rhythm resides in the suprachiasmatic nucleus (SCN) of the hypothalamus and coordinates autonomous peripheral clocks located in organs such as the liver and kidney. The molecular clock is composed of transcriptional feedback loops in organisms ranging from cyanobacteria to humans. Two transcription fact...

Co-expression of perforin and granzyme B genes induces apoptosis and inhibits the tumorigenicity of laryngeal cancer cell line Hep-2.

Granzyme B and perforin, two of the most important components, have shown anticancer properties in various cancers, but their effects in laryngeal cancer remain unexplored. Here we decided to examine the effects of Granzyme B and perforin in Hep-2 cells and clarify the role of perforin and granzyme B in the tumorigenicity of laryngeal cancer cell line. Hep-2 cells were transfected with pVAX1-PI...